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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often characterized by a focus on practical aspects of the study design, such as the recruitment and consent process, adherence, and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographic areas. This type of heterogeneity which is essential for a pragmatic trial to be reliable and 프라그마틱 무료체험 슬롯버프 무료스핀 (http://tongcheng.jingjincloud.cn/home.php?mod=space&uid=162529) reduce bias in results, is also necessary. However, too much heterogeneity can result in issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are typically ordered by policymakers and practitioners to help guide their decisions. They also provide a useful way to identify the causality between an intervention and its outcomes. However, they should not be used to replace explanatory studies.

The pragmatism idea is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials, which inform the policy and practice of. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic research study, including recruitment, design, implementation of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the subject of pragmatic thinking. It is important to keep in mind that the majority were conducted in primary-care settings.