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Pragmatic trials are studies designed to inform the real-world practice of clinical. They are typically described as a focus on the practical aspects of design, including the recruitment and consent process, as well as adherence and the use of standard equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, 프라그마틱 불법 체험 [bookmarkport.Com] which employed different investigators and participants from various geographical areas. This type of heterogeneity, which is vital for a pragmatic trial to be valid and reduce bias in results, is also necessary. However, too much heterogeneity, can cause problems with the trial design.
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The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. Usually, they are ordered by policymakers and practitioners to guide their decisions. They can also be a great way to identify the causality between an intervention and its outcomes. They should not, however, be used to replace explanation studies.
The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which prove a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the issue of pragmatics. It is important to remember that the majority of studies were conducted in primary-care settings.