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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically characterized by a focus on the practical aspects of study design, including the recruitment and consent process in adherence, as well as the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographic areas. This type of heterogeneity, which is essential for pragmatic trials to be valid and to reduce bias in the results, is also necessary. However, too much heterogeneity can lead to issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are usually ordered by policymakers and practitioners in order to guide their decisions. They can also be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used as a substitute for explanation studies.

The concept of pragmatism is controversial, and 프라그마틱 순위 there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and 프라그마틱 무료게임 pragmatic trials that inform the practice and policy decisions. They also suggested an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a practical trial, including recruitment, design and delivery of the intervention, and the follow-up.

There is an encouraging increase in the number pragmatic trials published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. However, it is important to remember that the majority of these trials were conducted in primary care settings.