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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of study design that include the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from different geographic areas. This type of heterogeneity, which is vital for a pragmatic trial to be valid and lessen the chance of bias is also essential. However, too much heterogeneity could cause issues with the design of the trial.

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The aim of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. They should not, however be used to replace explanatory studies.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should serve as a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove a physiological or clinical hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also suggested an approach to pragmatic trials, dubbed PRECIS.2 This tool sought to define the features of a pragmatic study which includes the recruitment process, 프라그마틱 슬롯 the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of studies were conducted in primary-care settings.