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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized by their focus on practical aspects of design, including recruitment and consent, adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographic areas. This kind of heterogeneity is necessary for pragmatic trials to be valid and helps reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They are also a good way to identify the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used in lieu for explanation trials.

The pragmatism idea is controversial and there are doubts about whether pragmatic trials can replace tests for explanations or 프라그마틱 슬롯체험 if they should serve as a complement to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a practical trial which includes recruitment, design and delivery of the intervention, and the follow-up.

There is a growing increase in the number pragmatic trials that have been published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials that are randomized (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.